Virginie MONNIER                                Version française               

Maître de Conférences ECL

INL
Site Ecole Centrale de Lyon
Batiment F7
36, Avenue Guy de Collongue
69134 Ecully
France

Tel : (33).04 72 18 62 39

E-mail : virginie.monnier@ec-lyon.fr

Localisation : F7 3ème étage


Research activities

Department : Biotechnologies / Santé

Group : Chimie et Nanobiotechnologies

Activities :


C.V.


Publications (last 5 years)

Articles Conférences invitées Communications
 

Articles (4)

Polyamidoamine Dendrimers as Crosslinkers for Efficient Electron Transfer between Redox Probes onto Magnetic Nanoparticles
F. Chen, N. Haddour, M. Frenea-Robin, Y. Chevolot, V. Monnier, , , , , , , , , , , , , , ,
ChemistrySelect 3 2823-2829 2018       
Impact of Ag@SiO2 core-shell nanoparticles on the photoelectric current of plasmonic inverted organic solar cells
K. N'Konou, M. Chalh, V. Monnier, N. Blanchard, Y. Chevolot, B. Lucas, S. Vedraine, P. Torchio, , , , , , , , , , , ,
Synthetic Metals 239 22-28 2018       
Shape-selective purification of gold nanorods with low aspect ratio using a simple centrifugation method
M. Boksebeld, N. Blanchard, A. Jaffal, Y. Chevolot, V. Monnier
Gold Bulletin 50 69-76 2017 AbstractThis work presents a new and simple procedure for the shape selective purification of gold nanorods from a mixture of rods and spheres. Previously reported methods were time-consuming and revealed several drawbacks such as low yields and difficulty to recover the purified nanoparticles. Additionally, they were mostly applied to high aspect ratio (AR) nanorods. Our process is based on only simple and short centrifugation steps in order to precipitate specifically gold nanospheres. Samples containing low AR nanorods (AR < 6) were selected to perform the purification process. The supernatant content was followed by UV-Visible absorption spectroscopy after each centrifugation step. Then, transmission electron microscopy (TEM) allowed extract the purification efficiency thanks to shape analyses performed on more than 1000 nanoparticles. These results showed that our centrifugation process was applied successfully to three sizes of nanorods (2.4, 3.7, and 5.3). High purification yields of 72 and 78% were attained for AR = 3.7 and AR = 5.3 nanorods, respectively.       
Folate-modified silicon carbide nanoparticles as multiphoton imaging nanoprobes for cancer-cell-specific labeling
M. Boksebeld, V. Kilin, A. Geloen, G. Ceccone, A. Jaffal, C. Schmidt, S. Alekseev, V. Lysenko, J. Wolf, L. Bonacina, E. Souteyrand, Y. Chevolot, V. Monnier
RCS Advances 7 27361-27369 2017 AbstractInterest in multiphoton microscopy for cell imaging has considerably increased over the last decade. Silicon carbide (SiC) nanoparticles exhibit strong second-harmonic generation (SHG) signal, and can thus be used as nonlinear optical probes for cell imaging. In this study, the surface of SiC nanoparticles was chemically modified to enable cancer-cell-specific labeling. In a first step, an aminosilane was grafted onto the surfaceof SiC nanoparticles. The resulting nanoparticles were further modified with folic acid, using an isothiocyanate-based coupling method. Nanoparticles from different functionalization steps were investigated by zeta potential measurement, colorimetric titration, infrared and ultraviolet-visible (UV-Vis) absorption spectroscopy, X-ray photoelectron spectroscopy (XPS), and time-of-flight secondary ion mass spectrometry (ToF-SIMS). Characterization results confirmed successful covalent grafting of silane and folic acid to nanoparticle surface. Finally, the efficacy of these folate-modified SiC nanoparticles for cancer-cell-specific labeling was evaluated by multiphoton microscopy, by measuring SHG-emitting cell area on multiphoton images. The average cancer-cell labeling percentage was about 48%, significantly higher than for negative controls (healthy cells, competition assay and poly(ethylene glycol) modified-SiC nanoparticles), where it ranged between 10% and 15%. These results demonstrated good efficiency and specificity for these folate-modified SiC nanoparticles in cancer-cell-specific labeling.       

Conférences invitées (2)

Nanoparticules plasmoniques hybrides pour l'imagerie médicale et la photothérapie
V. Monnier, , , , , , , , , , , , , , , , , , ,
Workshop "Matériaux Moléculaires pour les applications biomédicales" Montpellier, France 29-30 mai 2018       
Multi-functionalization of magnetic nanoparticles for biosensing applications
V. Monnier
C'Nano 2017 INSA Lyon 5-7 décembre 2017       

Communications (4)


Electroactive Magnetic Nanoparticles for Electrochemical Signal Amplification under Magnetic Attraction on a Microchip Device
M. Frenea-Robin, F. Chen, N. Haddour, Y. Chevolot, V. Monnier, , , , , , , , , , , , , , ,
MagMeet-12th International Conference on the Scientific and Clinical Applications of Magnetic Carriers Copenhagen, Danemark 22-26 mai 2018       
Double functionalization of magnetic colloids with electroactive molecules and antibody for platelet detection and separation
F. Chen, N. Haddour, M. Frenea-Robin, Y. Merieux, Y. Chevolot, V. Monnier, , , , , , , , , , , , , ,
BioNanoMed 2017 Krems (Autriche) 20-22 mars 2017       
Double functionalization of magnetic colloids with electroactive molecules and antibody for platelet detection and separation
F. Chen, N. Haddour, M. Frenea-Robin, Y. Merieux, Y. Chevolot, V. Monnier, , , , , , , , , , , , , ,
ChinaNANO 2017 Pékin (Chine) 29-31 août 2017       
Comment adapter un jeu d'entreprise pour enseigner la Chimie en école d'ingénieur ?
J.P. Cloarec, V. Monnier, N. Haddour, G. Le Mauff, J. Berthet
QPES 2015 Brest, France 17-19 juin 2015 AbstractNous présentons la transformation d'un cours de Chimie Moléculaire classique (Cours Magistral & Travaux Dirigés) en une formation associant les principes d'un jeu d'entreprise et d'un apprentissage par problème. Nous abordons également la question de l'appropriation du nouveau format par d'autres enseignants-chercheurs.